This example opens the Windows calculator (calc) and makes some input like using the keyboard.
import win32com.client import win32api shell = win32com.client.Dispatch("WScript.Shell") shell.Run("calc") win32api.Sleep(100) shell.AppActivate("Calculator") win32api.Sleep(100) shell.SendKeys("1{+}") win32api.Sleep(500) shell.SendKeys("2") win32api.Sleep(500) shell.SendKeys("~") # ~ is the same as {ENTER} win32api.Sleep(500) shell.SendKeys("*3") win32api.Sleep(500) shell.SendKeys("~") win32api.Sleep(2500)